Figure 4.
The effect of EGb-761 (Gb) or vehicle administered 3 h post-surgery on thermal hyperalgesia. (a) The mean thermal withdrawal latency (in seconds) measured in the incised paw in adult male rats (n=6–7 per group). Responses were measured before, 2, 4, 6, 24, 48, 72 and 192 h post-surgery. 30 mg kg−1 (†††) and 300 mg kg−1 (***) significantly attenuated hyperalgesia: P<0.001 vs vehicle. (b) The effect of all doses of EGb-761 (3, 10, 30, 100 and 300 mg kg−1), diclofenac (5 mg kg−1) or vehicle on thermal hyperalgesia. Maximum change in thermal latency in the ipsilateral (ipsi) and contralateral (contra) paw post-surgery is represented as mean % change (Emax %) from the pre-surgery/baseline response thresholds. Significant attenuation of hyperalgesia: **P<0.01; ***P<0.001 vs vehicle. AO, anaesthesia only.