Figure 5.

The effect of EGb-761 (Gb) or vehicle administered 3 h post-surgery on mechanical allodynia. (a) The mean mechanical threshold (in force/g) measured in the ipsilateral hindpaw in adult male rats (n=7–10). Responses were measured before, 2, 4, 6, 24, 48, 72 and 192 h post-surgery. Arrow represents time of Gb administration. (b) The effect of all doses of EGb-761 (3, 10, 30, 100 and 300 mg kg⁻¹), diclofenac (5 mg kg⁻¹) or vehicle administered 3 h post-surgery on mechanical allodynia in both hindpaws. Maximum change in mechanical response threshold in the ipsilateral (ipsi) and contralateral (contra) paw post-surgery is represented as mean % change (E_max %) from the pre-surgery/baseline response thresholds. EGb-761 had no effect on paw incision-induced allodynia. AO, anaesthesia only.