Figure 1.
Effect of A-251179 on membrane potential responses in guinea-pig bladder smooth muscle cells. (a) The traces shown are fluorescence responses to DiBAC4(3) triggered by application of varying concentrations of A-251179 and its reversal by glyburide (5 μM) as indicated. Inset: chemical structure of A-251179. (b) Concentration-response relationship of the membrane potential effects in comparison with ZD-6169 and (−)-cromakalim. Data are normalized to fluorescence responses evoked by a reference KATP channel opener, P1075 (10 μM).