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. 2007 Apr 16;151(4):467–475. doi: 10.1038/sj.bjp.0707249

Figure 2.

Figure 2

Effect of A-251179 on activating KATP currents in HEK293T cells transfected with SUR2A/Kir6.2 and SUR2B/Kir6.2 subunits. (a) Activation of membrane currents by A-251179 (100 nM) and pinacidil (PCN, 100 nM) in HEK293 cells transfected with SUR2A/Kir6.2 and SUR2B/Kir6.2 is depicted. The evoked currents were inhibited by 3 μM glyburide (GLB). (b) A-251179 evoked concentration-dependent increases in SUR2A/Kir6.2 (solid squares) and SUR2B/Kir6.2 (solid circles) currents. The peak currents evoked by A-251179 at each concentration was normalized to that evoked by 100 μM pinacidil.