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Effect of temperature on the association rate, dissociation rate and pKL of [3H]clobenpropit at histamine H3-receptors in guinea-pig cerebral cortex membranes
| Temperature (°C) | Temperature (K) | k+1 (M−1 min−1) | k−1 (min−1) | pKL |
|---|---|---|---|---|
| 30 | 303 | 77.26±5.29 × 108 | 3.32±0.50 × 10−1 | 10.37±0.10 |
| 21 | 294 | 7.49±1.32 × 108 | 0.44±0.06 × 10−1 | 10.27±0.27 |
| 12 | 285 | 10.60±0.84 × 108 | 0.33±0.05 × 10−1 | 10.60±0.12 |
| 4 | 277 | 6.37±3.3 × 108 | 0.047±0.001 × 10−1 | 11.01±0.20 |
Data are the mean±s.e.m. of three experiments.
