Table 1.
Population estimates of PK parameters (micro constants) for isoprenaline in the rat and estimates of the BS replicates
| Parameter | Value (CV) | Value (CV) BS |
|---|---|---|
| Structural parameters | ||
| K10 (min−1) | 1.32 (20.5%) | 1.33 (21.5%) |
| K12 (min−1) | 0.391 (36.1%) | 0.412 (39.8%) |
| K21 (min−1) | 0.177 (17.6%) | 0.177 (20.2%) |
| V1 (ml) | 79.6 (24.4%) | 83.3 (26.1%) |
| Interindividual variability (IIV) | ||
| ωK122 | 0.213 (46.8%) | 0.215 (54.1%) |
| ωK212 | 0.114 (43.8%) | 0.121 (103.0%) |
| ωV12 | 0.0982 (47.1%) | 0.0900 (49.5%) |
| Residual error | ||
| σPD2 | 0.0796 (22.4%) | 0.0760 (22.7%) |
Abbreviations: BS, bootstrap; CV, coefficient of variation; k10 represents the elimination rate constant, k12 and k21 represent the rate constants describing the transport from and to the second compartment; V1, central volume of distribution (first compartment); ω2, variance of ɛ; σ2, variance of η.