Table 3.
Population parameter estimates including variabilities and BS replicates for CL, V1, V2, V3 and Q2, Q3
| Parameter | Value (CV) | Value (CV) BS |
|---|---|---|
| Structural parameters | ||
| CL (ml min−1) | 11.7 (3.4%) | 11.7 (3.5%) |
| V1 (ml) | 115 (7.4%) | 114 (8.6%) |
| Q2 (ml min−1) | 15.0 (7.2%) | 15.2 (10.8%) |
| V2 (ml) | 173 (7.7%) | 172 (8.1%) |
| Q3 (ml min−1) | 8.50 (5.3%) | 8.50 (5.6%) |
| V3 (ml) | 849 (4.2%) | 848 (4.2%) |
| Inter-individual variability (IIV) | ||
| ωCL2 | 0.033 (9.8%) | 0.032 (19.9%) |
| ωV22 | 0.170 (28.2%) | 0.169 (29.6%) |
| ωV32 | 0.023 (36.7%) | 0.022 37.5%) |
| ωCL,V32 (covariance) | 0.026 (31.9%) | 0.024 (30.8%) |
| Residual error | ||
| σPD2 | 0.027 (9.5%) | 0.027 (9.6%) |
Abbreviations: BS, bootscrap; CL, clearance; CV, coefficient of variation; Q2, inter-compartmental clearance between first and second compartment; Q3, inter-compartmental clearance between first and third compartment; V1, central volume of distribution first compartment; V2, volume of distribution of second compartment; V3, volume of distribution of third compartment.