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. 2007 Apr 23;151(3):377–383. doi: 10.1038/sj.bjp.0707233

Figure 2.

Figure 2

(a) Akt expression was increased during reperfusion (30 min) and its phosphorylation significantly enhanced. When mice were pretreated with LY-294002 (30 mg kg−1) or geldanamycin (GA; 1 mg kg−1), Akt upregulation was reversed; S, sham; IR, ischemia-reperfusion; **P<0.01 vs vehicle (V). (b) Similarly, administration of LY-294002 (30 mg kg−1) or GA (1 mg kg−1) restored CAV-1 expression, but prevented the increase in eNOS expression and phosphorylation **P<0.01 vs sham (S). The blots are representative of three different experiments.