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. 2007 Apr 30;151(5):713–720. doi: 10.1038/sj.bjp.0707258

Table 2.

Population pharmacodynamic parameter estimates of morphine EEG effect obtained with the sigmoidal Emax model after hysteresis minimisation with the extended catenary biophase distribution model

Parameter Estimate CV% LLCI–ULCI
Structural model
E0 (μV) 44.6 2.3 42.6–46.6
Emax (μV) 44.5 8.0 37.5–51.5
EC50 (ng ml−1) 451 17.3 298–604
nH 2.32 10.4 1.85–2.79
       
Interindividual variability
ω2 kE0 0.034 17.8 0.022–0.045
ω2 kEmax 0.121 24.1 0.064–0.178
       
Residual variability
 Proportional error 0.027 7.6 0.023–0.031

Abbreviations: CV%, coefficient of variation; E0, no-drug response; Emax, intrinsic activity; EC50, measure of potency; nH, slope factor; LLCI, lower limit of confidence interval; ULCI, upper limit of confidence interval.