Table 1.

Experimental design of the studies investigating the PK–PD relationships of the EEG effects of morphine in rats

Dose (mg kg−1)	Treatment	Method	N	Body weight (kg)	Perfusate concentration (ng ml−1)
					0	50	500
4	Vehicle	EEG	7	0.294±0.023	N/A	N/A	N/A
		EEG/MD	14	0.297±0.014	N=10	N=3	N=3
		MD	3	0.304±0.023	N=3
	GF120918	EEG/MD	20	0.300±0.030	N=10	N=5	N=5
10	Vehicle	EEG	7	0.260±0.015	N/A	N/A	N/A
40	Vehicle	EEG	5	0.273±0.026	N/A	N/A	N/A
		EEG/MD	15	0.306±0.019	N=9	N=3	N=3

Abbreviations: EEG,electroencephalogram; MD, multidrug resistance; N/A, not applicable.