Figure 1.

Effects of heparinase-derived LMWH fractions on fMLP-induced elastase release from (a) unprimed and (b) TNF-α-primed neutrophils. Data are expressed as % of control elastase release (fMLP; 10⁻⁷ M), without heparin in (a) saline- and (b) TNF-α (10 ng ml⁻¹)-treated cells, respectively. Values were corrected for basal release under the relevant conditions and represent the mean±s.e.m of experiments with cells from six separate donors, each performed in duplicate. Statistical significance (P<0.05) is indicated (^*) from control release (100%). fMLP, formyl-Met-Leu-Phe; LMWH, low molecular weight heparin.