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. 2007 May 29;151(6):860–869. doi: 10.1038/sj.bjp.0707275

Figure 6.

Figure 6

Effect of concomitant i.c.v. injection of a selective antagonist of B2 receptors and Thr6-BK or BK on antinociceptive actions of the kinins. (a) Time course of the latencies in the tail flick test induced by concomitant i.c.v. injection of B2-receptor antagonist (Ant B2) and Thr6-BK (4 nmol) or B2-receptor antagonist and BK (8 nmol). (b) AUC of the groups shown in A. (c) Time course of the increase in latencies in the hot-plate test induced by concomitant i.c.v. injection of B2-receptor antagonist and Thr6-BK (4 nmol) or B2-receptor antagonist and BK (8 nmol). (d) AUC of the groups shown in C. *Significantly different from B2-receptor antagonist alone (*P<0.05 **P<0.001); #significantly different from the B2-receptor antagonist and Thr6-BK (4 nmol); and + significantly different from the B2-receptor antagonist and BK (8 nmol). AUC, area under the curve of antinociception; IA, index of antinociception; Thr6-BK, threonine6-bradykinin.