Table 2.

Activity of mitochondrial enzymes in heart

	Control	Doxorubicin (B)	Doxorubicin+dexrazoxane (C)	P-value (B vs control)	P-value (C vs control)	P-value (C vs B)
COXa	54±24	14±10	45±12	<0.001	0.30	<0.001
SDHa	60±26	75±39	51±17	0.37	0.38	0.11
COX/SDH-ratiob	100±18	26±22	99±16	<0.001	0.88	<0.001
CSa	3440±470	4346±694	3730±433	0.004	0.19	0.04

Abbreviations: COX, cytochrome c-oxidase; SDH, succinate dehydrogenase.

The values represent group means±s.d.

^aμmoles min⁻¹ g⁻¹ protein⁻¹;

^b% of control mean.