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Effect of NR2A(F637) mutations on desensitization kinetics. (a) Traces illustrating desensitization of current activated by 300 μM glutamate (in the presence of 50 μM glycine) in lifted cells expressing wild-type (WT) NR1/NR2A, NR1/NR2A(F637W) and NR1/NR2A(F637M) subunits. (b) Average values of Iss:Ip of glutamate-activated current; n=5–8 cells. Asterisks indicate values that differed significantly (ANOVA and Dunnett's test; **P<0.01) from the value for WT NR1/NR2A subunits.
