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. 2007 May 21;151(6):749–757. doi: 10.1038/sj.bjp.0707254

Figure 6.

Figure 6

Mutations at NR2A(F637) can alter mean open time of the NMDA receptor. Traces are currents activated by glutamate, 10 μM, in the presence of 50 μM glycine and 10 μM EDTA in cell-attached patches in cells expressing wild-type NR1/NR2A (a) or NR1/NR2A(F637W) (b) subunits. The pipette potential was −50 mV; channel openings are downward. Open time histograms from cell-attached patches containing wild-type NR1/NR2A (c) or NR1/NR2A(F637W) (d) subunits. Solid curves indicate maximum likelihood multiple exponential fits to the data and dotted curves indicate the individual exponential components. Traces in (a) and (b) and corresponding distributions in (c) and (d) are from the same individual patches; similar results were obtained in two to four other patches.