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. 2007 May 21;151(6):798–806. doi: 10.1038/sj.bjp.0707278

Figure 3.

Figure 3

Inhibition of BKCa currents by A-272651. Membrane currents, mediated by BKCa αβ1-subunits (a) and BKCa α-subunit stably transfected in HEK-293 cells (b), were evoked by testing potentials from −40 to +100 mV for 400 ms (20 mV each step) from a holding potential of 80 mV in control and in the presence of 3 μM A-272651. (c) Shows the concentration-dependent inhibition of currents, with IC50 values of 4.59±0.07 μM (Hill coefficient=1.04, measured at +40 mV) for BKCa α and 2.82±0.09 μM (Hill coefficient=0.89) for BKCa αβ1, respectively.