Figure 4.

Mean±s.e. mean values for serum 17β-estradiol concentrations for vehicle and five 17β-estradiol dosed groups (doses expressed as bolus+infusion in ng kg⁻¹+ng kg⁻¹ min⁻¹, respectively) in male and female rats. Sample numbers in each group range from 6 to 23 as it was not always possible to obtain a blood sample from each rat. ^*P<0.05 compared to the male vehicle group, ^#P<0.05 compared to the female vehicle group, Kruskal Wallis test. P-values indicated on the histogram for male/female comparisons were obtained using the Mann–Whitney U test.