Figure 1.

Na⁺ current transients recorded in the absence and in the presence of 100 μM Mex, 300 μM PHM, 300 μM HMM, 500 μM NHM and 1 mM NMG. In each group of traces, the greatest one has been recorded in the absence of drug, with a depolarizing step from the HP of −100 to −20 mV for 10 ms. A similar depolarizing stimulus applied after the application of each compound allowed to estimate the tonic block exerted by the drug (middle traces). The smallest current traces correspond to the residual current at end of the 10 Hz stimulation protocol.