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. 2006 Aug 21;149(3):300–310. doi: 10.1038/sj.bjp.0706867

Figure 5.

Figure 5

Concentration–response curves obtained with Mex and its metabolites PHM, HMM and NHM, constructed at the HPs values of −140 and at −70 mV. The curves fitting the experimental points were obtained using the logistic function described in Methods and allowed the calculation of the IC50 values (in Table 3). Each value is the mean±s.e.m. from four to seven fibres of the percentage block of INa in the presence of each concentration of drugs versus INa in the absence of the drug in the same fibre.