Figure 1.
The metabolic pathway of 5-fluorouracil. DPD, dihydropyrimidine dehydrogenase; EU, ethynyluracil; FdUMP, 5-fluorodeoxyuridine monophosphate; FUMP, 5-fluorouridine monophosphate; 5-FUTP, 5-fluorouridine triphosphate; 5-FUR, 5-fluorouridine; 5-dUdR, 5-deoxyuridine; H25-FU, dihydro-5-fluorouracil; FBal, fluoro-beta-alanine; PPRT, pyrimidine phosphoribosyl transferase; TK, thymidine kinase; ThdPh, thymidine phosphorylase; Urd Ph, uridine phosphorylase. Inactive metabolites (5-FUR, FBal, Urea, CO2) are in bold italics.