Table 2.
Pharmacokinetic parameters (median, range) of ceftazidine following bolus injection or consrant infusion.
| Overall (n = 21) | Bolus (n = 11) | Infusion (n = 10) | |
|---|---|---|---|
| Vz (l kg−1) | 0.468 (0.241–0.573) | 0.450 (0.254–0.573) | 0.486 (0.241–0.569) |
| K10 (min−1) | 7.53 (0.93–21.3) | 3.48 (0.93–21.3) | 11.58 (7.2–15.72) |
| AUC (mg l−1 h) | 1496 (251–8834) | ||
| t½,z (h) | 7.74 (1.95–44.71) | 11.89 (1.95–44.71) | 3.59 (2.65–5.78) |
| Css (mg l−1) | 75.5 (34–89.5) | ||
| Cmax (mg l−1) | 89.6 (69.8–157.5) | ||
| CL (l kg−1 h−1) | 0.058 (0.005–0.159) | 0.027* (0.005–0.159) | 0.089* (0.038–0.125) |
*
P < 0.05 Mann–Whitney U-test comparing bolus vs infusion groups.