Table 3.
Estimated creatinine clearance (ml min−1) | Bolus dosage (total in 24 h) | Loading dose for infusion (mg kg−1) | Infusion rate (mg kg−1 h−1) (total over 24 h) |
---|---|---|---|
50 | 40 mg kg−1 every 8 h (120) | 20 | 3.5 (84.0) |
31–50 | 20 mg kg−1 every 12 h (80) | 20 | 1.2 (28.8) |
15–30 | 20 mg kg−1 every 24 h (20) | 20 | 0.6 (14.4) |
< 15 | 10 mg kg−1 every 24 h (10) | 20 | 0.3 (7.2) |
Bolus dosage (loading dose in mg kg−1 and dose interval, total dose (mg kg−1) over 24 h in brackets) Infusion dosage (Loading dose inmg kg−1 and infusion rate, total dose (mg.kg−1) over 24 h in brackets).