Figure 3.

a) Individual concentration for BUD 22R-and 22S-epimers (solid line and dashed line, respectively) for all nine subjects. The bold line shows the biased fit of the mono-exponential absorption mono-exponential disposition model. b) Shows the less biased description of the data with two subjects removed. These two subjects require a two compartment disposition model to accurately characterize their pharmacokinetics, resulting in a more sustained budesonide concentration between 4 and 12 h postdose.