Table 1.
Model independent analysis of the steady state plasma pharmacokinetics of R-and S-budesonide (BUD) and fluticasone (FP) after repeat dose inhalation. Geometric mean (95% confidence intervals).
| R-BUD | S-BUD | FP | |
|---|---|---|---|
| Cmax (ng ml−1) | 1.8 (1.4–2.3) | 1.7 (1.2–2.2) | 0.26 (0.18–0.36) |
| tmax (h) | 0.46 (0.34–0.64) | 0.43 (0.30–0.61) | 0.63 (0.35–1.14) |
| t½,elim* (h) | 2.3 (1.3–4.1) | 2.3 (1.3–4.0) | 2.7 (1.4–5.2) |
| AUC (ng ml−1.h) | 6.1 (4.4–8.5) | 5.5 (3.7–8.3) | 0.85 (0.49–1.48) |
| AUC (% under data) | 85 (76–94) | 85 (78–92) | 86 (83–90) |
| CL/F (l h−1) | 163 (118–225) | 182 (121–273) | 1171 (677–2025) |
| t½,abs* (min) | 6.3 (3.8–10.3) | 5.7 (3.3–9.8) | 9.8 (4.0–24) |
| MRTobs (h) | 3.90 (2.41–6.32) | 3.85 (2.40–6.18) | 4.2 (2.40–7.36) |
| Vdss/F (l) | 600 (400–900) | 660 (453–963) | 4150 (2094–8225) |
*
Absorption and elimination half-life, calculated as natural log(2)/ka and natural log(2)/k, respectively.