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Population pharmacokinetic parameters for BUD after repeated dose administration from a pMDI in seven men using mixed effects model.
| Parameter | Estimate | Standard error |
|---|---|---|
| k12 (h−1) | 3.82 | 0.598 |
| V/F (l) | 498 | 62.4 |
| k20 (h−1) | 0.284 | 0.0134 |
| ω11* | 1.34 | 0.833 |
| ω22* | 0.076 | 0.0465 |
| ω33* | – | – |
| σ11 | 0.148 | 0.0152 |
The variances of η (Equation 8) refer to the random effects on k12 (absorption rate constant), V/F, and k20 (elimination rate constant), respectively. ω33 could not be estimated with confidence.
