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Pharmacokinetic parameters for FP after repeated dose administration from a pMDI in nine men using a mixed effects model.
| Parameter | Estimate | Standard error |
|---|---|---|
| k12 (h−1) | 3.67 | 0.846 |
| V/F (l) | 8100 | 1240 |
| k20 (h−1) | 0.0893 | 0.0085 |
| ω11* | 4.73 | 3.49 |
| ω22* | 0.261 | 0.108 |
| ω33* | – | – |
| σ11 | 0.167 | 0.0583 |
The variances of η (Equation 8) to the random effects on k12 (absorption rate constant), V/F, and k20 (elimination rate constant), respectively. ω33 could not be estimated with confidence.
