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Mean plasma concentrations of R(+) and S(–)-amlodipine after a 10 mg oral dose to 20 healthy male subjects consuming either grapefruit juice or water (placebo). ― placebo, R-enantiomer; - - - grapefruit juice, R-enantiomer; · · · · placebo, S-enantiomer; - · - · - grapefruit juice, S-enantiomer.
