Table 3.
Maximum change in blood pressure (mmHg) and pulse rate (beats min−1).
| Parameter | Intravenous amlodipine with: Grapefruit juice | Water (control) | Oral amlodipine with: 95% CI | Grapefruit juice | Water (control) | 95%CI |
|---|---|---|---|---|---|---|
| Supine | ||||||
| Systolic BP (mmHg) | −15.9 ± 13.4 | −11.8 ± 6.7 | −10.4, 2.1 | −11.7 ± 8.8 | −9.2 ± 5.9 | −8.7, 3.7 |
| Diastolic BP (mmHg) | −10.1 ± 7.3 | −11.5 ± 6.2 | –3.1, 6.0 | −11.5 ± 5.0 | −13.2 ± 7.2 | −2.9, 6.3 |
| Pulse (beats min−1) | 9.0 ± 4.2 | 12.7 ± 7.0 | –7.7, 0.4 | 14.4 ± 7.8 | 13.5 ± 6.5 | −3.2, 4.9 |
| Standing | ||||||
| Systolic BP (mmHg) | −20.9 ± 11.8 | −18.8 ± 8.8 | –8.2, 3.9 | −14.8 ± 9.4 | −11.9 ± 6.1 | −8.9, 3.1 |
| Diastolic BP (mmHg) | −11.7 ± 5.4 | −13.3 ± 6.7 | –2.5, 5.6 | −13.3 ± 6.6 | −13.0 ± 5.8 | −4.4, 3.7 |
| Pulse (beats min−1) | 20.1 ± 8.8 | 25.1 ± 11.0 | –9.8, −0.2⋆ | 15.2 ± 6.5 | 15.8 ± 9.5 | −5.4, 4.2 |
⋆
Adjusted mean ± s.d. values Treatment difference P < 0.05, intravenous amlodipine plus grapefruit juice vs intravenous amlodipine plus water.