Table 1.
Effect of α1-acid glycoprotein on the intracellular accumulation of saquinavir, ritonavir and indinavir
| Intracellular concentration of protease inhibitor (µm) | |||
|---|---|---|---|
| Concentration of AGP | Saquinavir [95% CI] | Ritonavir [95% CI] | Indinavir [95% CI] |
| 0 mg ml−1 | 31.5 ± 4.5 (100%) | 8.8 ± 1.1 (100%) | 3.0 ± 0.3 (100%) |
| 0.5 mg ml−1 | 11.8 ± 0.9a (37.5%) | 3.2 ± 0.7a (36.4%) | 1.3 ± 0.1a (43.3%) |
| [15.0–24.4] | [3, 4, 7, 9] | [1, 1–3] | |
| 2.0 mg ml−1 | 7.4 ± 1.8a,b (23.5%) | 1.6 ± 0.7a,b (18.2%) | 1.5 ± 0.1a (50%) |
| [19,4–28,8] | [5.4–9.0] | [1, 1, 1, 9] | |
Data are expressed as mean ± s.d., n = 4 (four separate experiments on different days). Statistical analysis performed by anova followed by a t-test (Bonferroni) accepting P < 0.05 as being significant.
a
P < 0.0001 compared with control (0 mg ml−1 AGP)
b
P < 0.05 compared with 0.5 mg ml−1 AGP. Values in brackets are the percentage of control. AGP—α1-acid glycoprotein. CI—95% confidence interval for mean differences compared with control.