Table 2.
Population pharmacokinetics of thioTEPA and TEPA (basic model).
| Parameter | Population value (RSD)1 | Interindividual variability (%) (RSD)1 | Interoccasion variability (%) (RSD)1 |
|---|---|---|---|
| CL (l h−1) | 34.5 (0.098) | 16 (0.45) | 15 (0.50) |
| V1 (l) | 45.8 (0.072) | 7.4 (2.8) | 19 (0.64) |
| k12 (h−1) | 0.273 (0.20) | ||
| k21 (h−1) | 0.459 (0.41) | 47 (1.1) | |
| fm* (l−1) | 0.0298 (0.20) | 36 (0.34) | 26 (0.41) |
| k (h−1) | 0.584 (0.18) | 21 (0.44) | 26 (0.50) |
| k34 (h−1) | 2.79 (0.22) | ||
| k43 (h−1) | 0.855 (0.088) | 24 (0.51) | |
| Proportional error thioTEPA (%) | 27.7 | ||
| Additive error thioTEPA (µm) | 0.0631 | ||
| Proportional error TEPA (%) | 20.9 |
1
RSD = relative standard error of estimate.