Table 3.

Results of final backward elimination procedure.

Model: CL = θ₁ + θ₉*(AP-57) + θ₁₀*(ALB-43); V₁ = θ₂ + θ₁₁*>(TP-61); k₁₂ = θ₃; k₂₁ = θ₄, fm*= θ₅; k = θ₆ + θ₁₂*(WGT-68); k₃₄ = θ₇; k₄₃ = θ₈.

Eliminated parameter	Covariable	Objective function	ΔObjective function1	P value2
Basic population model	−2784.966
Full population model	−2876.405
θ9 CL	Alkaline phosphatase	−2853.050	+ 23.355	< 0.0005
θ10 CL	Serum albumin	−2864.130	+ 12.275	0.0005
θ11V1	Total protein	−2856.818	+ 19.227	< 0.0005
θ12k	Body weight	−2840.364	+ 36.041	< 0.0005

¹Difference in objective function between indicated model and full population model.

²P value calculated using the likelihood ratio test indicating the difference between the indicated (reduced) model and the full population model.