Table 2.

Details of the 18 patients who developed systemic (nondermal) side-effects to N-acetylcysteine

Number	F/M	Age (years)	Dose	TNAC	Asthma	Allergy	Side-effects
1	F	21	13 g	3 h	0	0	Rash, pruritus, bronchospasm
2	F	17	20 g	6 h	0	0	Rash, bronchospasm
3	F	19	20 g	27 h	0	0	Rash, flushing, nausea, vomiting
4	M	36	28 g	60 h	0	0	Nausea, discomfort
5	M	27	25 g	20 h	0	0	Flushing, nausea, bronchospasm
6	F	16	10 g	10 h	0	0	Pruritus, angioedema
7	M	44	60 g	67 h	0	0	Pruritus, vomiting, dizziness, local pain
8	F	18	23 g	15 h	0	+	Pruritus, flushing, vomiting
9	F	16	15 g	48 h	+	+	Pruritus, flushing, nausea, angioedema, sneezing
10	F	34	18 g	9 h	0	0	Rash, pruritus, flushing, angioedema
11	F	14	20 g	45 h	+	0	Nausea, bronchospasm
12	F	18	5 g	17 h	0	0	Rash, pruritus, flushing, hypotension, bronchospasm
13	F	49	50 g	60 h	0	0	Rash, burning sensation, fever
14	M	38	5 g	18 h	0	0	Flushing, nausea, sweating, chest pain
15	F	26	20 g	5 h	+	0	Rash, flushing, coughing
16	M	49	25 g	42 h	0	0	Rash, angioedema
17	F	19	10 g	38 h	+	0	Chest pain
18	F	33	25 g	32 h	0	0	Rash, pruritus, angioedema

TNAC=time to N-acetylcysteine.