Table 3.
Biochemical and clinical data in all patients admitted with paracetamol poisoning. A subset of patients who were not comatose upon admittance was constructed
| Total (n = 529) Side-effects (n = 45) | No side-effects (n = 484) | Subset (n = 473) Side-effects (n = 44) | No side-effects (n = 429) | |
|---|---|---|---|---|
| Prothrombin (arbitary units) | 0.29 (0.21–0.50) | 0.24 (0.13–0.48) | 0.29 (0.21–0.53) | 0.27 (0.14–0.53) |
| ALT (units l−1) | 2510 (28–66400 | 3085 (29–9635) | 2760 (29–7145) | 2660 (26–9750) |
| Bilirubin (µmol l−1) | 26 (13–45) | 33 (14–85)* | 27 (13–47) | 30 (13–73) |
| Platelets (×109 l−1) | 198 (129–227) | 150 (83–208)* | 200 (130–227) | 161 (96–214)* |
| Creatinine (µmol l−1) | 87 (74–98) | 91 (77–166) | 88 (75–103) | 87 (76–121) |
| S-paracetamol (mmol l−1) | 0.07 (0.01–0.63) | 0.51 (0.09–1.26)* | 0.07 (0.01–0.63) | 0.52 (0.10–1.24)* |
| Coma on admission | 1/45 (2.2%) | 54/484 (11%) | – | – |
| Hepatic encephalopathy | 2/45 (4.4%) | 80/484 (17%)† | 1/44 (2.3%) | 40/429 (9.3%) |
| Plasmapheresis | 0/45 (0%) | 37/484 (7.6%) | 0/44 (0%) | 19/429 (4.4%) |
| Haemodialysis | 3/45 (6.7%) | 35/484 (7.2%) | 3/44 (6.8%) | 27/429 (6.3%) |
| Liver transplant | 0/45 (0%) | 5/484 (1.0%) | 0/44 (0%) | 4/429 (0.9%) |
| Death | 0/45 (0%) | 32/484 (6.6%) | 0/44 (0%) | 16/429 (3.7%) |
Values are given as median (1st quartile-3rd quartile).
*
Mann–Whitney: P < 0.05
†
Chi-square: P < 0.05.