Table 1.
Mean birth weight, and proportion of low birth weight, high birth weight and preterm birth among the offspring of 315 Danish and 73 Scottish women who purchased diuretics during pregnancy.
| Birth weight (g) | Low birth weight | High birth weight | Preterm birth | |||||
|---|---|---|---|---|---|---|---|---|
| n in ATC groups | Means.d. | Mean diff*1–595% CI | number% | OR*1–395% CI | number% | OR*1–395% CI | number% | OR*1–395% CI |
| NJPD, Denmark | ||||||||
| Reference population=46,998 | 3510.2 | 720 1.5 | 8957 19.1 | 2482 5.3 | ||||
| Overall n = 315 | 3439.8 719.5 | 26.6−25.2, 78.4 | 10 3.2 | 1.7 1.1, 2.7 | 63 20.0 | 1.1 0.8, 1.4 | 32 10.2 | 1.8 1.2, 2.7 |
| Loop n = 83 | 3570.8 732.9 | 104.7 2.6, 206.9 | 0 | – | 21 25.3 | 1.3 0.7, 2.1 | 9 10.8 | 1.6 0.7, 3.7 |
| Thiazide n = 232 | 3401.3 712.4 | 6.5−53.7, 66.2 | 10 4.3 | 2.6 1.4, 5.0 | 42 18.1 | 1.0 0.7, 1.4 | 23 9.9 | 1.9 1.2, 3.0 |
| MEMO, Scotland | ||||||||
| Reference population = 35,798 | 3394.1 562.9 | 749 2.1 | 4509 12.5 | 1854 5.2 | ||||
| Overall n = 73 | 3318.5 550.1 | −48.7−151.2, 53.8 | 4 5.5 | 1.8 0.7, 5.1 | 7 9.6 | 0.7 0.3, 1.6 | 7 9.6 | 1.9 0.9, 4.3 |
| Loop n = 31 | 3237.1 515.4 | −117.7−273.8, 38.5 | 1 3.2 | 1.0 0.1, 7.8 | 1 3.2 | 0.2 0, 1.6 | 4 12.9 | 2.7 1.0, 7.9 |
| Thiazide n = 42 | 3378.6 573.1 | −3.4−132.4, 139.3 | 3 7.1 | 2.4 0.8, 7.8 | 6 14.3 | 1.1 0.5, 2.7 | 3 7.1 | 1.4 0.4, 4.6 |
Number of women who used diuretics during pregnancy are given as overall (ATC C03) and within ATC groups; loop diuretics (ATC C03C) and thiazide (ATC C03A and C03B). Crude values of birth weights are given as mean values with standard deviations (s.d.). Crude values of low birth weight, high birth weight and preterm delivery are given as numbers and percentages. Analyses adjusted for maternal ag*1, smoking*2 (NJPD), cohabitation status (NJPD) and Carstairs scores (MEMO)*3, gender of the child*4 and gestational age in completed weeks*5. Results from these analyses are given as mean differences and ORs with 95% confidence intervals (CI).