Table 1.
PRL-inducing dose equivalencies for prolactin release, therapeutic dose and receptor affinities for antipsychotic drugs. (See text for explanation of PRL-inducing dose equivalence).
| Drug | Maintenance dose (mg day−1) | Reported study range (mg) | PRL-inducing dose equivalencies | D2 receptor affinityKi (nm) [49] | 5-HT2/D2ratio [49] |
|---|---|---|---|---|---|
| Amisulpride | 300–1200 | 20–400 | 56.6 | ||
| DU-29895 | ? | 3–10 | 2 | ||
| Remoxipride | 60–300 | 0.5–150 | 9.29 | 272 | > 40 |
| Sulpiride | 100–200 | 100–400 | 97.8 | 31 | 40 |
| Zetidoline | 10–30 | 10–40 | 0.81 | ||
| Raclopride | 4–8 | 0.1–16 | 1.72 | 7.0 | 1429 |
| Mazapertine | ? | 5–50 | – | ||
| Zotepine | 50–300 | 25–100 | 17.2 | 13 | 0.07 |
| Pimozide | 2–6 | 2–6 | 7.89 | 1.2 | 5 |
| Setoperone | 15–120 | 5–40 | 14 | ||
| Olanzapine | 5–20 | 3–5 | – | ||
| Clozapine | 150–300 | 12.5–50 | 309 | 152 | 0.02 |
| Risperidone | 4–8 | 1–2 | 0.1 | 3.1 | 0.05 |
| Chlorpromazine | 75–300 | 25–100 | 39.6 | 19 | 0.14 |
| Prochlorperazine | 25–50 | 2.5–5 | 8.3 | 3.1 | 2.4 |
| Trifluoperazine | 20–30 | 4 | 5.1 | 4.3 | 2 |
| Perphenazine | 16–64 | 1 | 2 | 6.5 | 0.66 |
| Haloperidol | 4–10 | 0.25–10 | 1.11 | 1.2 | 2.3 |
| Fluphenazine | 2.5–5 | 0.35 | 1.89 | 1.9 | 1.8 |
| Thiotixene | 20–30 | 0.25–0.5 | 0.56 | 2.5 | 39 |
| Thiethylperazine | 10 | 10 | 4.37 | 4.5 | 11 |
| Molindone | 30–100 | 5 | 1.13 | 25 | 94 |
| Thioridazine | 200–800 | 10–75 | – | 16 | 0.26 |