Table 1.
Comparison of pharmacokinetic parameters between healthy and liver disease subjects after single oral dosing of 10 mg sabeluzole tablet.
| Healthy subjects (n = 10) | Liver disease subjects (n = 10) | 95% CI for difference | Statistical significance | |
|---|---|---|---|---|
| tmax (h) | 2.4 ± 0.9 | 2.3 ± 1.1 | −0.78; 0.98 | NS |
| Cmax (ng ml−1) | 21.6 ± 9 | 25.9 ± 11.0 | −4.51; 13.11 | NS |
| AUC(0,24h) (ng ml−1 h) | 158 ± 110 | 255 ± 56 | 20.5; 173.5 | P < 0.05 |
| AUC(0,∝) (ng ml−1 h) | 331 ± 282 | 681 ± 200 | 135.7; 564.3 | P < 0.01 |
| λz (h−1) | 0.0741 ± 0.087 | 0.0191 ± 0.0055 | 0.00087–0.109 | NS |
| t½λz (h) | 17.5 ± 10.2 | 39.3 ± 11.5 | 12.3; 31.3 | P < 0.001 |
Data represent mean±s.d. NS: no significant.