Table 1.
Summary statistics for pharmacokinetic parameters of simvastatin hydroxy acid on day 8 of 40 mg day−1 simvastatin administration alone and together with 4 mg lacidipine.
| Simvastatin alone | Simvastatin+lacidipine | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Age (years) | Weight (kg) | AUC(0,24 h) (ng ml−1 h) | Cmax(ng ml−1) | t1/2 (h) | tmax (h) | AUC(0,24 h) (ng ml−1h) | Cmax(ng ml−1) | t1/2 (h) | tmax (h) | |
| Mean | 28.8 | 67.0 | 66.50 | 10.03 | 9.7 | 1.3 | 88.20 | 18.35 | 10.0 | 2.2 |
| s.d. | 7.2 | 8.5 | 26.34 | 5.53 | 5.9 | 1.1 | 37.70 | 14.83 | 6.5 | 1.9 |
| CV% | 39.6 | 55.2 | 60.4 | 81.1 | 42.7 | 80.8 | 65.0 | 84.9 | ||
| Median | 67.4 | 8.14 | 9.0 | 1.0 | 80.07 | 15.35 | 8.1 | 1.5 | ||
| Minimum | 19 | 54 | 14.44 | 3.65 | 3.8 | 0.5 | 28.01 | 5.14 | 3.5 | 0.5 |
| Maximum | 40 | 80 | 109.06 | 22.15 | 25.6 | 4.0 | 177.07 | 68.14 | 28.6 | 6.0 |
Cmax = peak plasma concentration, tmax = time to reach Cmax, AUC(0,24 h) = area under the plasma concentration-time curve from 0 to 24 h, Mean = arithmetic mean, s.d. = standard deviation, CV% = coefficient of variation percentage.