Table 2.

Estimates of geometric mean values (and 95% confidence intervals) of the simvastatin-acid pharmacokinetic parameters and treatment comparisons, expressed as ratios of treatment estimates, together with 90% confidence intervals.

			Ratio estimate
Simvastatin-acid pharmacokinetic parameter	Simvastatin alone (A)	Simvastatin+Lacidipine (B)	B/A	90% CI	P value
AUC(0,24 h) (ng ml−1 h)	60.36 (47.15, 77.28)	80.96 (64.62, 101.44)	135%	118%, 153%	0.001
Cmax (ng ml−1)	8.76 (6.72, 11.41)	14.89 (10.77, 20.58)	169%	120%, 237%	0.016
t1/2 (h)	8.5 (6.6, 10.9)	8.5 (6.4, 11.4)	101%	77%, 132%	0.955
tmax (h)	1.0 (0.5, 4.0)†	1.5 (0.5, 6.0)†	0.5 (h)§	0.0, 2.0 (h)§	0.143

^†Median and range

^§Estimate is median difference between the two treatments.