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. 2001 Feb;51(2):133–142. doi: 10.1111/j.1365-2125.2001.01292.x

Table 3.

Kinetic parameters of astemizole metabolism by human liver microsome and recombinant CYP3A4 or CYP2D6

Reactions Enzyme
graphic file with name bcp0051-0133-mu1.jpg
graphic file with name bcp0051-0133-mu2.jpg
DES-AST formation Human liver microsome 0.94 203
cDNA-expressed CYP2D6 0.82 7.7
NOR-AST formation Human liver microsome 9.2 203
cDNA-expressed CYP3A4 30.0 16.1
6OH-AST formation Human liver microsome 1.0 (Km1) 33.5(Vmax1)
3.9 (Km2) 109 (Vmax2)
cDNA-expressed CYP3A4 9.8 7.5
cDNA-expressed CYP2D6 0.96 12.0

a) μm, b) pmol min−1 mg−1 protein for human liver microsome and nmol min−1 nmol−1 P450 for recombinant P450 systems.