Table 2.

Secondary pharmacokinetic parameters for morphine, M3G, and M6G represented as median values (range).

	Morphine		M3G		M6G
Parameter	Morphine+ OND	Morphine+ NS	Morphine+OND	Morphine+ NS	Morphine+OND	Morphine+NS
CL r (l h−1)	5.9 (1.1,8.1)	6.8 (3.8,9.9)	4.7 (2.1,6.2)	4.9 (1.6,7.3)	10.9 (4.2,15.2)	12.0 (2.8,21.3)
AUC ratio	NA	NA	8.5 (5.1,11.1)	7.9 (6.1,10.1)	0.8 (0.5,1.1)	0.7 (0.5,1.3)
(metabolite: morphine)
fe (%)	7.0 (1.2,11.4)	7.7 (5.7,13.1)	38.3 (17.8,58.8)	42.9 (19.3,51.0)	9.6 (3.7,12.5)	10.0 (4.0,11.7)

CL r, renal clearance; fe, percent of dose excreted in urine as each analyte.