Table 2.
Mean PK/PD parameters for saccadic peak velocity and diastolic blood pressure for fast infusion and difference slow-fast infusion.
| Mean | 95% CI | Interindividual variability (s.d.) | |
|---|---|---|---|
| Saccadic peak velocity1 | |||
| t1/2Ke0 (min) | 5.6 | 1.5/9.7 | 0.0 (fixed) |
| Intercept fast infusion | 445 | 418/472 | 32 |
| Difference in intercept (slow-fast) | 11.8 | −6.9/30.5 | 16 |
| Slope fast infusion | −11.3 | −14.0/−8.6 | 1.3 |
| Difference in slope (slow-fast) | −1.1 | −3.1/0.8 | 0.0 |
| Residual error (s.d.) | 31.2 | ||
| Diastolic blood pressure2 | |||
| Intercept fast infusion | 61.4 | 58.2/64.6 | 3.1 |
| Difference in intercept (slow-fast) | 2.2 | −0.9/5.3 | 0.9 |
| Slope fast infusion | −1.20 | −1.68/−0.72 | 0.13 |
| Difference in slope (slow-fast) | −0.48 | −1.12/0.16 | 0.29 |
| Residual error (s.d.) | 4.29 | ||
1
units for intercepts in °/s; units for slopes in (°/s)/(ng ml−1).
2
units for intercepts in mmHg; units for slopes in (mmHg)/(ng ml−1).