Table 1.
Pharmacokinetic parameters for BDP, B-17-MP and BOH following intravenous administration of BDP.
| Analyte | AUC(0,∞) (pg ml−1 h) | Cmax (pg ml−1) | tmax (h) | CL (l h−1) | Vss (l) | MRT (h) | t½ (h) |
|---|---|---|---|---|---|---|---|
| BDP | 6660 | 35356 | 0.2* | 150 | 20 | 0.1 | 0.5* |
| (4385–10117) | (20244–61748) | (0.2–0.3) | (98.8–228) | (10.6–39.4) | (0.1–0.2) | (0.3–0.7) | |
| B-17-MP | 6185 | 2633 | 0.2* | 120 | 424 | 3.5 | 2.7* |
| (5361–7135) | (2158–3211) | (0.2–0.8) | (104–139) | (362–496) | (3.0–4.1) | (1.3–5.3) | |
| BOH | 126*# | 57.2* | – | – | – | – | |
| (0–557) | (0–113) |
Values are geometric mean (95% CI) except values denoted with
*
which are median (range).
#
Denotes AUC(0,t).