Table 2.

Pharmacokinetic parameters for B-17-MP following administration of BDP orally and intranasally with and without activated charcoal.

Group	AUC (pg ml−1 h)	Cmax (pg ml−1)	tmax (h)	t1/2 (h)	MRT (h)	MAT (h)
Oral	10158	703	4.0*	8.8*	15.7	11.7
	(6757–15270)	(563–879)	(1.5–6.0)	(4.9–47.7)	(11.1–22.0)	(7.8–17.5)
Oral with charcoal	231*#	99.9*	1.5*	–	–	–
	(0–2159)	(0–361)	(0.3–6.0)
Intranasal	3660	310	4.0*	5.7*	12.4	7.6
	(2220–6036)	(256–375)	(4.0–8.0)	(2.6–109.5)	(7.1–21.8)	(3.7–15.8)
Intranasal with charcoal	89.4#	66.8*	1.5*	–	–	–
	(0–1799)	(0–251)	(1.0–6.0)

Values are geometric mean (95% CI) except values denoted with

^*which are median (range).

^#Denotes AUC(0,t).