Table 3.
Pharmacokinetic parameters for BDP and B-17-MP following administration of BDP via the inhaled route with and without activated charcoal.
| Group | Analyte | AUC (pg ml−1 h) | Cmax (pg ml−1) | tmax (h) | t1/2 (h) | MRT (h) | MAT (h) |
|---|---|---|---|---|---|---|---|
| Inhaled | BDP | 151 | 319 | 0.3* | – | – | – |
| (84.6–269) | (184–553) | (0.2–0.5) | |||||
| B-17-MP | 3851 | 944 | 1.0* | 2.7* | 4.1 | 0.6 | |
| (2831–5238) | (671–1327) | (0.8–6.0) | (2.1–3.6) | (3.5–4.6) | (−2.1–1.8) | ||
| Inhaled | BDP | 217# | 459 | 0.5* | – | – | – |
| with charcoal | (134–353) | (294–716) | (0.2–0.5) | ||||
| B-17-MP | 2383 | 705 | 0.8* | 2.3* | 3.5 | −0.2 | |
| (1541–3686) | (436–1141) | (0.8–1.0) | (1.7–5.8) | (3.0–4.0) | (−2.2–2.3) |
Values are geometric mean (95% CI) except values denoted with
*
which are median (range).
#
Denotes AUC(0,t).