Table 1.
Summary of demographic characteristics and inclusion criteria of healthy controls and patients with cirrhosis.
| Healthy subjects (n = 12) | Moderate cirrhosis (n = 12) | Severe cirrhosis without ascites (n = 7) | Severe cirrhosis with ascites (n = 5) | ||
|---|---|---|---|---|---|
| Sex | Female | 4 | 4 | 3 | 1 |
| Male | 8 | 8 | 4 | 4 | |
| Age | Mean±s.d. | 50 ± 8.9 | 49 ± 8.9 | 51 ± 11.8 | 53 ± 6.7 |
| (years) | Median (range) | 53 (35–59) | 52 (37–59) | 55 (31–61) | 53 (46–61) |
| Height | Mean±s.d. | 171 ± 7.5 | 169 ± 7.6 | 168 ± 9.2 | 167 ± 8.3 |
| (cm) | Median (range) | 171 (158–180) | 168 (152–185) | 168 (155–180) | 170 (155–176) |
| Weight | Mean±s.d. | 71.2 ± 9.9 | 78.4 ± 15.2 | 67.1 ± 14.6 | 69.9 ± 12.8 |
| (kg) | Median (range) | 71.1 (55.0–88.2) | 79.5 (46.0–105.0) | 65.0 (50.0–92.0) | 73.0 (53.5–84.0) |
| Child-Pugh Score | Median | 5 | 9 | 12 | |
| at screening | Min–Max | 5–5 | 7–10 | 10–13 | |
| – Prothrombin activity | 375% | 355% | < 55% | < 55% | |
| Biological | – Serum bilirubin | ≤ 22 µmol l−1 | ≤ 60 µmol l−1 | > 60 µmol l−1 | > 60 µmol l−1 |
| criteria | – Serum albumin | ≥ 40 g l−1 | ≥ 28 g l−1 | < 28 g l−1 | < 28 g l−1 |
| – Biopsy-proven cirrhosis | No | Yes | Yes | Yes | |
| Clinical criteria | – History of ascites or hepatic encephalopathy | No | No or | Yes or Yes* | |
| – Recent gastrointestinal haemorrhage | No | No | Yes or | Yes or | |
| – Portal hypertensive gastropathy | No | No | Yes or | Yes or | |
| – Oesophageal varices | No | No | Yes | Yes |
*
> 5 l of ascitic fluid with clinical signs of fluid thrill or shifting dullness.