. 2001 May;51(5):443–450. doi: 10.1046/j.1365-2125.2001.01372.x

Table 1.

Pharmacokinetic parameters of methylprednisolone after a single 48 mg oral dose before and after repeated administration of itraconazole for 4 days to 14 subjects.

	C_max (ng ml⁻¹)	t_max (h)	t_1/2 (h)	AUC(0,24 h) (ng ml⁻¹ h)
Methylprednisolone	453 [401,505]	2 (1–4)	3.2 [2.5–3.9]	2773 [2223,3323]
Methylprednisolone+itraconazole	713 [637,788]	3 (1–5)	5.5 [5.2,5.9]	7011 [6275,7747]
Differences between means	260^* [177,343]	–	2.25^* [1.5,3]	4238^* [3421,5055]

Data are mean [95% CI]; t_max is given as median (range). C_max peak plasma concentration, t_max time to C_max, t_1/2 elimination half-life, AUC area under the plasma concentration-time curve.

paired t-test : P < 0.001.