. 2001 May;51(5):443–450. doi: 10.1046/j.1365-2125.2001.01372.x

Table 2.

Pharmacokinetic parameters of prednisolone after a single 60 mg oral dose before and after repeated administration of itraconazole for 4 days to 14 subjects.

	C_max (ng ml⁻¹)	t_max (h)	t_1/2 (h)	AUC(0,24 h) (ng ml⁻¹ h)
Prednisolone	587 [532,642]	2 (1–4)	3.7 [3.3,4.1]	3860 [3365,4356]
Prednisolone + itraconazole	668 [592,744]	3 (1–5)	4.2 [3.7,4.7]	4571 [3997,5145]
Differences between means	81 [−5,167]	–	0.5 [−0.2,1.2]	710 [−69,1489]

Data are mean [95% CI]; t_max is given as median (range). C_max peak plasma concentration, t_max time to C_max, t_1/2 elimination half-life, AUC area under the plasma concentration-time curve.