Table 3.
Pharmacokinetics parameters of cortisol after methylprednisolone (MP) 48 mg or prednisone (PN) 60 mg with or without itraconazole treatment (itra).
| C24 h (ng ml−1) | AUC(0,24 h) (ng ml−1 h) | tmin (h) | Elimination rate constant (h−1) | |
|---|---|---|---|---|
| MP | 109* [68,149] | 1933 [1073,2793] | 15 (8–24) | 5.6 [3.2,8] |
| MP+itra | 24* [5,43] | 1790 [896,2684] | 24 (0–24) | 7.0 [4.9,9.1] |
| Difference between means | −85 [−123,−46] | −143 [−499,211] | – | 1.4 [−0.4,3] |
| PN | 173* [142,203] | 2010 [727,3293] | 4 (1–18) | 3.2 [0.1,6.3] |
| PN+itra | 185* [149,221] | 2031 [913,3149] | 4.5 (1.5–18) | 3.7 [0.8,6.6] |
| Difference between means | 12 [−24,49] | 21 [−921,964] | – | 0.5 [−0.4,1.4] |
| Simple contrasts | MP+itra = MP | NS | MP = PN | NS |
| MP+itra = PN | MP+itra = PN | |||
| MP+itra = PN+itra | MP+itra = PN+itra | |||
| MP = PN+itra | MP = MP+itra | |||
| MP = PN | PN = PN+itra | |||
| PN = PN+itra | MP = PN+itra |
Data are mean [95% CI], tmin is given as median (range). C24 h cortisol concentrations at 24 h, AUC area under the cortisol concentration-time curve, tmin time to reach the lowest concentrations of cortisol.
*
anova : P < 0.001, °anova : P < 0.01.