Table 1.

Milk and plasma concentrations, and M/P ratios for quinapril and quinaprilat

Subject	Weight (kg)	Quinapril Dose weight adjusted (mg kg−1)	Plasma AUC(0,∝) (µg l−1 h)	Milk AUC (µg l−1 h)	M/P	Baby's dose weight adjusted (% maternal dose)	Quinaprilat Plasma AUC(0,∝) (µg l−1 h)	Milk* AUC (µg l−1 h)	M/P*
1	64	0.313	240	21.0	0.09	1.01	2824	< 60	< 0.02
2	87	0.230	215	27.8	0.13	1.81	2101	< 60	< 0.03
3	65	0.308	180	< 20.0	< 0.11	0.97	1955	< 60	< 0.03
4	57	0.351	241	35.5	0.15	1.52	1379	< 60	< 0.04
5	76	0.263	350	30.1	0.09	1.72	1763	< 60	< 0.03
6	105	0.190	239	32.8	0.14	2.59	1892	< 60	< 0.03
Mean	76	0.28	244	27.9	0.12	1.6	1985	< 60	< 0.03
s.d	18	0.06	57	6.3	0.03	0.6	478
95%CI			184,304	21.3,34.7	0.09,0.14	1.0,2.2	1484,2488

^*not detected in milk. These are ‘at worst’ estimates.