Table 1.
Pharmacokinetic parameters of oral 6-TG (40 mg m−2) administered in the fasting state and after food. *Subject 6 did not complete the pharmacokinetic study after food and hence was excluded from the analysis.
| Fasting | After food | |||||||
|---|---|---|---|---|---|---|---|---|
| Subject | Cmax (pmol ml−1) | tmax (h) | C6 (pmol ml−1) | AUC (pmol l−1h) | Cmax (pmol ml−1) | tmax (h) | C6 (pmol ml−1) | AUC (pmol ml−1 h) |
| 1 | 90 | 1.5 | 36 | 286 | 67 | 5.0 | 50 | 211 |
| 2 | 228 | 0.5 | 0 | 363 | 194 | 3.0 | 0 | 296 |
| 3 | 496 | 1.5 | 28 | 815 | 213 | 3.0 | 40 | 613 |
| 4 | 235 | 1.5 | 0 | 320 | 46 | 2.0 | 26 | 190 |
| 5 | 412 | 1.5 | 28 | 880 | 168 | 1.5 | 0 | 321 |
| 6* | 703 | 1.5 | 30 | 1318 | ||||
| 7 | 50 | 2.5 | 0 | 156 | 16 | 4.4 | 0 | 33 |
| 8 | 737 | 1.5 | 46 | 1306 | 75 | 1.5 | 0 | 96 |
| 9 | 55 | 3.1 | 25 | 168 | 18 | 6.0 | 18 | 25 |
| 10 | 391 | 1.0 | 50 | 809 | 61 | 4.1 | 26 | 117 |
| 11 | 695 | 1.5 | 39 | 1216 | 103 | 3.0 | 36 | 299 |
| Median | 313 | 1.5 | 28 | 586 | 71 | 3 | 22 | 200 |
| Range | 51–737 | 0.5–3.1 | 0–50 | 156–1306 | 16–213 | 1.5–6 | 0–50 | 25–613 |